Blood Plasma Products

Our products are made from blood plasma donated in Japan. As part of our work process, we perform virus testing on plasma, as well as the inactivation and removal of viruses during the manufacturing process. We also perform virus tests on final products to ensure the safety of all our blood plasma products. Under Japanese regulations, plasma-derived products cannot be exported.

History

The Japanese blood donation system began in 1964. The following year our intramuscular immunoglobulin was approved for use, followed by the approval of our albumin in 1966.

  • 1979: Launched Confact8 (Coagulation Factor VIII/von Willebrand Factor Complex)
  • 1980: Launched Venilon-I (Sulfonated Intravenous Immunoglobulin)
  • 1985: Launched ConfactF (Coagulation Factor VIII/von Willebrand Factor Complex)
  • 1991: Launched BOLHEAL (Fibrin Sealant)
  • 1992: Launched NovactM (Coagulation Factor IX Preparation)
  • 2001: Launched AnactC (Activated Protein C)
  • 2014: Launched Byclot (Coagulation Factor VIIa Containing Factor X)

Anact C Injection 2500 units

(Human Activated Protein C)

>Anact C Injection 2500 units
Indications :

The following diseases caused by congenital protein C deficiency

  1. Deep vein thrombosis, acute pulmonary thromboembolism
  2. Purpuric purpura
Storage :

Store at 10°C or below. Do not freeze.

Shelf life :

3 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Affinity chromatography
  • Nanofiltratin
  • Dry heat treatment (65°C, 96h)
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.

BOLHEAL Tissue Sealant

(Fibrin Sealant (Human))

BOLHEAL Tissue Sealant
Indications :

Tissue adhesion and closure

Storage :

Store at 10°C or below. Do not freeze.

Shelf life :

2 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Nanofiltratin
  • Dry heat treatment (Thrombin: 65°C/96h, Fibrinogen: 65°C/144h)
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.

Byclot Combination I.V. Injection

(Human Coagulation Factor VIIa containing Factor X)

Byclot Combination I.V. Injection
Indications :

Control of bleeding episodes in patients with blood coagulation factor VIII or factor IX deficiency with inhibitors.

Storage :

Keep away from light at 10°C or below. Do not freeze.

Shelf life :

3 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Anion exchange chromatography
  • Affinity chromatography
  • Solvent/detergent treatment
  • Nanofiltration
  • Dry heat treatment (65°C, 96h)
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.

Confact F I.V. Injection 250 units, 500 units, 1000 units

(Human Coagulation Factor VIII/von Willebrand Factor Complex)

Confact F I.V. Injection 250 units, 500 units, 1000 units
Indications :
  1. Control of bleeding episodes in patients with blood coagulation factor VIII deficiency.
  2. Control of bleeding episodes in patients with von Willebrand disease.
Storage :

Store at 10°C or below. Do not freeze.

Shelf life :

3 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Ion exchange chromatography
  • Nanofiltratin
  • Dry heat treatment (65°C, 96h)
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.

Histaglobin S.C. Injection

Indications :
  1. Bronchial asthma
  2. Allergic rhinitis
  3. Vasomotor rhinitis
  4. Allergic skin diseases (urticaria, chronic eczema, and atopic dermatitis)
Histaglobin S.C. Injection
Storage :

Store between 2°C and 10°C. Do not freeze.

Shelf life :

3 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Ethanol fractionation
  • Nanofiltratin
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.

Kenketu Albumin20% I.V. injection 10g/50mL “KMB”,25% I.V. injection 12.5g/50mL “KMB”

(Human Albumin)

Indications :
  1. Hypoalbuminemia due to loss of albumin (burn injuries, nephrotic syndrome, etc.) and reduced albumin synthesis (liver cirrhosis, etc.).
  2. Hemorrhagic shock
Kenketu Albumin20% I.V. injection 10g/50mL “KMB”,25% I.V. injection 12.5g/50mL “KMB”
Storage :

Store at room temperature. Do not freeze.

Shelf life :

2 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Ethanol fractionation
  • Nanofiltratin
  • Liquid heat treatment (60°C, 10h)
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.

Kenketsu Venilon-I I.V. Injection 500 mg, 1000 mg, 2500 mg, 5000 mg

(Intravenous Immunoglobulin (Human))

Kenketsu Venilon-I I.V. Injection 500 mg, 1000 mg, 2500 mg, 5000 mg
Indications :
  1. Hypogammaglobulinemia or agammaglobulinemia
  2. Combined use with antibiotics in severe infections
  3. Idiopathic thrombocytopenic purpura (when other medications are ineffective and there is a remarkable bleeding tendency and temporary hemostasis management such as surgical treatment or delivery is required)
  4. Acute Kawasaki disease (in severe cases with a risk of coronary artery dysfunction)
  5. Guillain-Barre syndrome (in severe cases causing difficulties walking in the acute exacerbation phase)
  6. Improvement of neuropathy in eosinophilic polyangiitis granulomatosis (only when steroid drugs are ineffective)
Storage :

Store at 30°C or below. Do not freeze.

Shelf life :

2 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Ethanol fractionation
  • Sulfonation treatment
  • Nanofiltratin
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.

Novact M I.V. Injection 500 units, 1000 units, 2000 units

(Human Coagulation Factor IX)

Novact M I.V. Injection 500 units, 1000 units, 2000 units
Indications :

Control of bleeding episodes in patients with blood coagulation factor IX deficiency.

Storage :

Store at 30°C or below. Do not freeze.

Shelf life :

2 years

Virus inactivation/reduction :
  • Plasma material PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.
  • Anion exchange chromatography
  • Affinity chromatography
  • Nanofiltration
  • Dry heat treatment (65°C, 96h)
  • Final product PCR (NAT) testing for HIV, HBV, HCV, and parvovirus B19.